Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C.

@article{Maiese1995NeuroprotectionBP,
  title={Neuroprotection by peptide growth factors against anoxia and nitric oxide toxicity requires modulation of protein kinase C.},
  author={Kenneth Maiese and L Fraddosio Boccone},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={1995},
  volume={15 3},
  pages={440-9}
}
Basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) are neuroprotective during anoxia and nitric oxide (NO) toxicity. Signal transduction systems that modulate protein kinase C (PKC) also can modulate the toxic effects of anoxia and NO. We therefore examined whether PKC was involved in the protective effects of bFGF and EGF during anoxia and NO toxicity. Down-regulation or inhibition of PKC activity before anoxia or NO exposure prevented hippocampal neuronal degeneration… CONTINUE READING