Neuroprotection by histone deacetylase-related protein.

  title={Neuroprotection by histone deacetylase-related protein.},
  author={Brad E Morrison and Nazanin Majdzadeh and Xiaoguang Zhang and Aaron Lyles and Rhonda Bassel-Duby and Eric N Olson and Santosh R D'Mello},
  journal={Molecular and cellular biology},
  volume={26 9},
The expression of histone deacetylase-related protein (HDRP) is reduced in neurons undergoing apoptosis. Forced reduction of HDRP expression in healthy neurons by treatment with antisense oligonucleotides also induces cell death. Likewise, neurons cultured from mice lacking HDRP are more vulnerable to cell death. Adenovirally mediated expression of HDRP prevents neuronal death, showing that HDRP is a neuroprotective protein. Neuroprotection by forced expression of HDRP is not accompanied by… CONTINUE READING