Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta.

@article{Bruno1998NeuroprotectionBG,
  title={Neuroprotection by glial metabotropic glutamate receptors is mediated by transforming growth factor-beta.},
  author={Valeria Bruno and Giuseppe Battaglia and Gullermina Casabona and Agata G. Copani and Francesco Caciagli and Ferdinando Nicoletti},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1998},
  volume={18 23},
  pages={9594-600}
}
The medium collected from cultured astrocytes transiently exposed to the group-II metabotropic glutamate (mGlu) receptor agonists (2S,1'R, 2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV) or (S)-4-carboxy-3-hydroxyphenylglycine (4C3HPG) is neuroprotective when transferred to mixed cortical cultures challenged with NMDA (). The following data indicate that this particular form of neuroprotection is mediated by transforming growth factor-beta (TGFbeta). (1) TGFbeta1 and -beta2 were highly… CONTINUE READING

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