Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease.

@article{Borlongan2004NeuroprotectionBE,
  title={Neuroprotection by encapsulated choroid plexus in a rodent model of Huntington's disease.},
  author={Cesario V. Borlongan and Steve J M Skinner and Marilyn S. Geaney and Alfred V Vasconcellos and Robert B. Elliott and Dwaine F. Emerich},
  journal={Neuroreport},
  year={2004},
  volume={15 16},
  pages={2521-5}
}
Choroid plexus from neonatal pigs was encapsulated in alginate microcapsules and transplanted into the rat striatum. Three days later, the same animals received unilateral injections of quinolinic acid (225 nmol) into the ipsilateral striatum. Choroid plexus transplants ameliorated the weight loss and motor impairments resulting from QA. Histological analysis demonstrated that choroid plexus transplants reduced the volume of striatal damage and protected ChAT-, but not NADPH-diaphorase-positive… CONTINUE READING