Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.

  title={Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinson's disease.},
  author={Jinhui Chen and Kui Xu and Jacobus P Petzer and Roland G W Staal and Yong Hua Xu and Michael A. Beilstein and Patricia K. Sonsalla and Kay P Castagnoli and Neal Castagnoli and Michael A. Schwarzschild},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={21 10},
Recent epidemiological studies have established an association between the common consumption of coffee or other caffeinated beverages and a reduced risk of developing Parkinson's disease (PD). To explore the possibility that caffeine helps prevent the dopaminergic deficits characteristic of PD, we investigated the effects of caffeine and the adenosine receptor subtypes through which it may act in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin model of PD. Caffeine, at doses… CONTINUE READING
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Adenosine A2A antagonists with potent anti-cataleptic activity

  • J Shimada, N Koike, +8 authors F Suzuki
  • Bio Med Chem Lett
  • 1997
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Antiparkinsonian effect of a new selective adenosine A2A receptor antagonist in MPTP-treated monkeys

  • R Grondin, PJ Bédard, AH Tahar, L Grégoire, A Mori, H Kase
  • Neurology
  • 1999
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