Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway

@article{Zhou2008NeuroprotectionBP,
  title={Neuroprotection by PGE2 receptor EP1 inhibition involves the PTEN/AKT pathway},
  author={Ping Zhou and Liping Qian and Tsu Chou and C Iadecola},
  journal={Neurobiology of Disease},
  year={2008},
  volume={29},
  pages={543-551}
}
The prostanoid synthesizing enzyme cyclooxygenase-2 (COX-2) is involved in the mechanisms of cerebral ischemia, an effect mediated by prostaglandin E2 through activation of EP1 receptors. Thus, inhibition of EP1 receptors is neuroprotective in models of ischemic stroke, but the molecular mechanisms of the effect have not been fully elucidated. We used oxygen glucose deprivation (OGD) in hippocampal slices as an injury model to investigate whether the neuroprotection afforded by EP1 receptor… CONTINUE READING

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