Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways

@article{Almeida2005NeuroprotectionBB,
  title={Neuroprotection by BDNF against glutamate-induced apoptotic cell death is mediated by ERK and PI3-kinase pathways},
  author={Ramiro D. Almeida and Bruno J Manadas and Carlos Vin{\'i}cius Mota de Melo and Jo{\~a}o R Gomes and C{\'e}sar S. Mendes and M{\'a}rio Gr{\~a}os and Robson Francisco Carvalho and Ars{\'e}lio Pato Carvalho and Carlos B Duarte},
  journal={Cell Death and Differentiation},
  year={2005},
  volume={12},
  pages={1329-1343}
}
Neurotrophins protect neurons against glutamate excitotoxicity, but the signaling mechanisms have not been fully elucidated. We studied the role of the phosphatidylinositol 3-kinase (PI3-K) and Ras/mitogen-activated protein kinase (MAPK) pathways in the protection of cultured hippocampal neurons from glutamate induced apoptotic cell death, characterized by nuclear condensation and activation of caspase-3-like enzymes. Pre-incubation with the neurotrophin brain-derived neurotrophic factor (BDNF… CONTINUE READING
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