Neuroprotection against oxidative stress by estrogens: structure-activity relationship.

@article{Behl1997NeuroprotectionAO,
  title={Neuroprotection against oxidative stress by estrogens: structure-activity relationship.},
  author={Christian Behl and Thomas Skutella and Frank Lezoualc’h and Anke Post and Michelle Widmann and Christopher J. Newton and Florian Holsboer},
  journal={Molecular pharmacology},
  year={1997},
  volume={51 4},
  pages={
          535-41
        }
}
Oxidative stress-induced neuronal cell death has been implicated in different neurological disorders and neurodegenerative diseases; one such ailment is Alzheimer's disease. Using the Alzheimer's disease-associated amyloid beta protein, glutamate, hydrogen peroxide, and buthionine sulfoximine, we investigated the neuroprotective potential of estrogen against oxidative stress-induced cell death. We show that 17-beta-estradiol, its nonestrogenic stereoisomer, 17-alpha-estradiol, and some… Expand
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