Neuroprotection — rationale for pharmacological modulation of Na+-channels

Abstract

The primary factor detrimental to neurons in neurological disorders associated with deficient oxygen supply or mitochondrial dysfunction is insufficient ATP production relative to their requirement. As a large part of the energy consumed by brain cells is used for maintenance of the Na+ gradient across the cellular membrane, reduction of energy demand by… (More)
DOI: 10.1007/BF01345256

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