Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity. I. Fermentation, isolation, physico-chemical properties and biological activity.

@article{Kobayashi2001NeuroprotectinsAA,
  title={Neuroprotectins A and B, bicyclohexapeptides protecting chick telencephalic neuronal cells from excitotoxicity. I. Fermentation, isolation, physico-chemical properties and biological activity.},
  author={H. Kobayashi and K. Shin-ya and K. Nagai and K. Suzuki and Y. Hayakawa and H. Seto and B. Yun and I. Ryoo and J. S. Kim and C. J. Kim and I. Yoo},
  journal={The Journal of antibiotics},
  year={2001},
  volume={54 12},
  pages={
          1013-8
        }
}
Glutamate, an excitatory amino acid, is known to induce neurotoxicity in central nervous system under abnormal conditions such as ischemia, hypoglycemia, epilepsy, Huntington's chorea, Parkinson's disease and Alzheimer's disease. In our search for neuroprotective agents of microbial origin against excitatory neurotoxins, we have isolated two new bicyclohexapeptides, neuroprotectins A and B, together with a known compound complestatin, from the fermentation broth of Streptomyces sp. Q27107… Expand
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