Neuroprotectin D1 Attenuates Laser-induced Choroidal Neovascularization in Mouse

  title={Neuroprotectin D1 Attenuates Laser-induced Choroidal Neovascularization in Mouse},
  author={Kristopher G. Sheets and Yongdong Zhou and Monica K. Ertel and Eric J. Knott and Cornelius E. Regan and Jasmine R. Elison and William C. Gordon and Per Gjorstrup and Nicolas G Bazan},
  booktitle={Molecular vision},
PURPOSE To examine the effects of neuroprotectin D1 (NPD1), a stereospecific derivative of docosahexaenoic acid, on choroidal neovascularization (CNV) in a laser-induced mouse model. Specifically, this was assessed by clinically grading laser-induced lesions, measuring leakage area, and volumetrically quantifying vascular endothelial cell proliferation. METHODS C57Bl/6 mice were treated with vehicle control or NPD1, and choroidal neovascularization was induced by laser rupture of Bruch's… CONTINUE READING
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