Neuroprogesterone: key to estrogen positive feedback?

  title={Neuroprogesterone: key to estrogen positive feedback?},
  author={Paul E Micevych and Kiran K. Soma and Kevin Sinchak},
  journal={Brain research reviews},
  volume={57 2},
In the cycling female rat, estradiol and progesterone induce reproductive behavior and the surge of luteinizing hormone (LH) needed for ovulation. Circulating estradiol of ovarian origin induces progesterone receptors in the preoptic area and hypothalamus. Sequential activation of estrogen receptors (ER) and progesterone receptors coordinates reproductive physiology and behavior. In ovariectomized and adrenalectomized (ovx/adx) rats, administration of estradiol alone is sufficient to initiate… CONTINUE READING
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