442 Citations
The Neurotrophins and Neuropoietic Cytokines: Two Families of Growth Factors Acting on Neural and Hematopoietic Cells
- BiologyAnnals of the New York Academy of Sciences
- 1998
It is demonstrated that specific combinations of neurotrophic factors are required to influence the neuronal progenitor cells to become postmitotic mature CNS neurons, and synergistic interactions may play an important role in modulating the differentiation of a wide assortment of neuronal precursors in the developing nervous system.
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 2004
A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The np gene is localized in tandem with the cardiotrophin-1 gene on mouse chromosome 7. NP…
The emerging neuropoietic cytokine family: first CDF/LIF, CNTF and IL-6; next ONC, MGF, GCSF?
- Biology, MedicineCurrent Opinion in Neurobiology
- 1992
Cytokine receptors on glial cells
- BiologyGlia
- 1994
The function of the receptors for cytokines and families of differentiation/survival/growth factors as they operate on astrocytes, microglia, and oligodendrocyte in development, health, and disease is reviewed.
STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines.
- BiologyMolecular endocrinology
- 1994
Activation of STAT transcription factors contributes to the induction of the VIp gene by the CNTF family of cytokines and may be involved in cytokine-mediated differentiation of sympathetic neurons.
Activating mechanism of CNTF and related cytokines
- BiologyMolecular Neurobiology
- 2007
Structural-function analysis showed that the gp130-interactive proteins bind in a similar manner to that of growth hormone, and there should be other pathways and some crosstalk between them to enhance, prolong, or specify the signals.
Activins as candidate cholinergic differentiation factors in vivo
- BiologyInternational Journal of Developmental Neuroscience
- 1995
3 CNTF and Related Neurokines
- Biology
- 2006
This chapter will highlight the actions of the neurokines and the current state of the understanding of the signaling pathway, with emphasis on activation and inactivation processes, and discuss some potential roles in neurodegenerative diseases and their treatment.
References
SHOWING 1-10 OF 97 REFERENCES
Invertebrate cytokines: The phylogenetic emergence of interleukin‐1
- BiologyBioEssays : news and reviews in molecular, cellular and developmental biology
- 1989
Investigations of the evolution of cytokines will help to decipher the complex cellular, humoral and molecular interactions that regulate host defenses and studies of the invertebrates will shed light on the phylogenetic emergence of these molecules.
Identification of functional receptors for ciliary neurotrophic factor on neuronal cell lines and primary neurons
- BiologyNeuron
- 1990
The cholinergic neuronal differentiation factor from heart cell conditioned medium is different from the cholinergic factors in sciatic nerve and spinal cord.
- BiologyDevelopmental biology
- 1990
Sequence and structural organization of the human gene encoding ciliary neurotrophic factor.
- BiologyGene
- 1991
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor
- BiologyNature
- 1989
The complementary DNA-deduced amino-acid sequence and subsequent expression of cDNA clones covering the entire coding region in HeLa-cells indicate that CNTF is a cytosolic protein, and shows thatCNTF is not a target-derived neurotrophic factor.
Structural design and molecular evolution of a cytokine receptor superfamily.
- BiologyProceedings of the National Academy of Sciences of the United States of America
- 1990
This work proposes that the approximately 200-residue binding segment of the canonical cytokine receptor is composed of two discrete folding domains that share a significant sequence and structural resemblance with a likely binding site for cytokine ligands.
Separation and partial characterization of neuropeptide-inducing factors in heart cell conditioned medium
- BiologyNeuron
- 1990
Interleukin 3 as a trophic factor for central cholinergic neurons in vitro and in vivo
- BiologyNeuron
- 1990
The cholinergic neuronal differentiation factor from heart cells is identical to leukemia inhibitory factor.
- BiologyScience
- 1989
Structural analysis and biological assays demonstrated that this protein is identical to a protein that regulates the growth and differentiation of embryonic stem cells and myeloid cells, and that stimulates bone remodeling and acute-phase protein synthesis in hepatocytes.