Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance.

@article{Schmidt2017NeuroplastinAB,
  title={Neuroplastin and Basigin Are Essential Auxiliary Subunits of Plasma Membrane Ca2+-ATPases and Key Regulators of Ca2+ Clearance.},
  author={Nadine Schmidt and Astrid Kollewe and Cristina E Constantin and Sebastian Henrich and Andreas Ritzau-Jost and Wolfgang Bildl and Anja Saalbach and Stefan Hallermann and {\'A}kos Kulik and Bernd Fakler and U. Schulte},
  journal={Neuron},
  year={2017},
  volume={96 4},
  pages={827-838.e9}
}
Plasma membrane Ca2+-ATPases (PMCAs), a family of P-type ATPases, extrude Ca2+ ions from the cytosol to the extracellular space and are considered to be key regulators of Ca2+ signaling. Here we show by functional proteomics that native PMCAs are heteromeric complexes that are assembled from two pore-forming PMCA1-4 subunits and two of the single-span membrane proteins, either neuroplastin or basigin. Contribution of the two Ig domain-containing proteins varies among different types of cells… CONTINUE READING