Neuroplasticity and cellular resilience in mood disorders

@article{Manji2000NeuroplasticityAC,
  title={Neuroplasticity and cellular resilience in mood disorders},
  author={Husseini K. Manji and Gregory J. Moore and Grażyna Rajkowska and Guang Chen},
  journal={Molecular Psychiatry},
  year={2000},
  volume={5},
  pages={578-593}
}
Although mood disorders have traditionally been regarded as good prognosis diseases, a growing body of data suggests that the long-term outcome for many patients is often much less favorable than previously thought. Recent morphometric studies have been investigating potential structural brain changes in mood disorders, and there is now evidence from a variety of sources demonstrating significant reductions in regional CNS volume, as well as regional reductions in the numbers and/or sizes of… CONTINUE READING
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