Neuroplasticity: from MRI to depressive symptoms.

  title={Neuroplasticity: from MRI to depressive symptoms.},
  author={Philippe Fossati and Andrei Radtchenko and Patrice Boyer},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  volume={14 Suppl 5},
Morphological and functional changes have been repeatedly reported in the brain organization of depressed patients. The main modifications demonstrated by structural magnetic resonance imaging (MRI) are a reduction in the gray matter volume within the prefrontal cortex, the hippocampus, and the striatum. The reduction in gray matter volume and the morphological atrophy are probably due to an excess of neural loss (apoptosis) and an altered regulation of the neurotrophic processes. Hence, a… CONTINUE READING
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Down-regulation of the Trk-B signal pathway: the possible pathogenesis of major depression

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