Neuropilin signalling in angiogenesis.

  title={Neuropilin signalling in angiogenesis.},
  author={Sina Koch},
  journal={Biochemical Society transactions},
  volume={40 1},
VEGFs (vascular endothelial growth factors) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in adults. This family of five mammalian ligands acts through three RTKs (receptor tyrosine kinases). In addition, co-receptors such as NRPs (neuropilins) associate with the ligand-receptor signalling complex and modulate the output. Therapeutics to block several of the VEGF signalling components as well as NRP function have been… CONTINUE READING
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impairs developmental yolk sac and embryonic angiogenesis

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