Neuropilin-2 regulates a6b1 integrin in the formation of focal adhesions and signaling

Abstract

The neuropilins (NRPs) contribute to the function of cancer cells in their capacity as VEGF receptors. Given that NRP2 is induced in breast cancer and correlates with aggressive disease, we examined the role of NRP2 in regulating the interaction of breast cancer cells with the ECM. Using epithelial cells from breast tumors, we defined NRP2 and NRP2… (More)

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