Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation

@article{Roth2016Neuropilin1MV,
  title={Neuropilin-1 mediates vascular permeability independently of vascular endothelial growth factor receptor-2 activation},
  author={Lise Roth and Claudia Prahst and Tina Ruckdeschel and Soniya Savant and Simone Westr{\"o}m and Alessandro Fantin and Maria Riedel and M{\'e}lanie H{\'e}roult and Christiana Ruhrberg and Hellmut G Augustin},
  journal={Science Signaling},
  year={2016},
  volume={9},
  pages={ra42-ra42}
}
Neuropilin-1 (NRP1) regulates developmental and pathological angiogenesis, arteriogenesis, and vascular permeability, acting as a coreceptor for semaphorin 3A (Sema3A) and the 165–amino acid isoform of vascular endothelial growth factor A (VEGF-A165). NRP1 is also the receptor for the CendR peptides, a class of cell- and tissue-penetrating peptides with a specific R-x-x-R carboxyl-terminal motif. Because the cytoplasmic domain of NRP1 lacks catalytic activity, NRP1 is mainly thought to act… CONTINUE READING
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