Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.

@article{Wang2003Neuropilin1mediatedVP,
  title={Neuropilin-1-mediated vascular permeability factor/vascular endothelial growth factor-dependent endothelial cell migration.},
  author={Ling Wang and Huiyan Zeng and Ping Wang and Shay Soker and Debabrata Mukhopadhyay},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 49},
  pages={
          48848-60
        }
}
Neuropilin-1 (NRP-1) has been found to be expressed by endothelial cells and tumor cells as an isoform-specific receptor for vascular permeability factor/vascular endothelial growth factor (VEGF). Previous studies were mainly focused on the extracellular domain of NRP-1 that can bind to VEGF165 and, thus, enables NRP-1 to act as a co-receptor for VEGF165, which enhances its binding to VEGFR-2 and its bioactivity. However, the exact functional roles and related signaling mechanisms of NRP-1 in… CONTINUE READING
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