Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry.

@article{Ghez2006Neuropilin1II,
  title={Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry.},
  author={David Ghez and Yves Lepelletier and Sophie Lambert and Jean-Marie Fourneau and Vincent Blot and S{\'e}bastien Janvier and Bertrand Arnulf and Peter van Endert and Nikolaus Heveker and Claudine Pique and Olivier Hermine},
  journal={Journal of virology},
  year={2006},
  volume={80 14},
  pages={
          6844-54
        }
}
Human T-cell lymphotropic virus type 1 (HTLV-1) is transmitted through a viral synapse and enters target cells via interaction with the glucose transporter GLUT1. Here, we show that Neuropilin-1 (NRP1), the receptor for semaphorin-3A and VEGF-A165 and a member of the immune synapse, is also a physical and functional partner of HTLV-1 envelope (Env) proteins. HTLV-1 Env and NRP1 complexes are formed in cotransfected cells, and endogenous NRP1 contributes to the binding of HTLV-1 Env to target… CONTINUE READING

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