Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates semaphorin3a/collapsin-1-induced growth cone collapse by small diameter sensory afferents.

@article{Reza1999Neuropilin1IE,
  title={Neuropilin-1 is expressed on adult mammalian dorsal root ganglion neurons and mediates semaphorin3a/collapsin-1-induced growth cone collapse by small diameter sensory afferents.},
  author={Julie Naima Reza and Isabella Gavazzi and James R. Cohen},
  journal={Molecular and cellular neurosciences},
  year={1999},
  volume={14 4-5},
  pages={317-26}
}
Neuropilin-1 on the growth cones of NGF-dependent embryonic dorsal root ganglion (DRG) neurons mediates the repulsive effects of secreted semaphorin3a, but its role in adult neurons is unknown. Here we show that most adult rat DRG neurons, regardless of cell diameter/afferent phenotype, express neuropilin-1 protein in vitro. However, the response of growth cones belonging to these neurons (induced by recombinant collapsin-1/semaphorin3a and blocked by the anti-neuropilin-1 antibody) was… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 24 extracted citations

Similar Papers

Loading similar papers…