Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells

@inproceedings{Wang2015Neuropilin1I,
  title={Neuropilin 1 is an entry factor that promotes EBV infection of nasopharyngeal epithelial cells},
  author={Hongbo Wang and Hua Zhang and Jing-Ping Zhang and Yan Li and Bo Zhao and Guo-Kai Feng and Yong Du and Dan Xiong and Qian Zhong and Wan-Li Liu and Huamao Du and Man-Zhi Li and Wen-lin Huang and Sai Wah Tsao and Lindsey M. Hutt-Fletcher and Yi-xin Zeng and Elliott Kieff and Mu-sheng Zeng},
  booktitle={Nature communications},
  year={2015}
}
Epstein-Barr virus (EBV) is implicated as an aetiological factor in B lymphomas and nasopharyngeal carcinoma. The mechanisms of cell-free EBV infection of nasopharyngeal epithelial cells remain elusive. EBV glycoprotein B (gB) is the critical fusion protein for infection of both B and epithelial cells, and determines EBV susceptibility of non-B cells. Here we show that neuropilin 1 (NRP1) directly interacts with EBV gB(23-431). Either knockdown of NRP1 or pretreatment of EBV with soluble NRP1… CONTINUE READING
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