Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.

@article{Jiang2007Neuropilin1IA,
  title={Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.},
  author={Susan X. Jiang and Melissa Lynn Sheldrick and Angele Desbois and Jacqueline Slinn and Sheng Tao Hou},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 5},
  pages={
          1696-705
        }
}
The nuclear transcription factor E2F1 plays an important role in modulating neuronal death in response to excitotoxicity and cerebral ischemia. Here, by comparing gene expression in brain cortices from E2F1(+/+) and E2F1(-/-) mice using a custom high-density DNA microarray, we identified a group of putative E2F1 target genes that might be responsible for ischemia-induced E2F1-dependent neuronal death. Neuropilin 1 (NRP-1), a receptor for semaphorin 3A-mediated axon growth cone collapse and… CONTINUE READING

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