Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer.

@article{Battaglia2008Neuropilin1EI,
  title={Neuropilin-1 expression identifies a subset of regulatory T cells in human lymph nodes that is modulated by preoperative chemoradiation therapy in cervical cancer.},
  author={Alessandra Battaglia and Alexia Buzzonetti and Giovanni Monego and Laura Peri and Gabriella Ferrandina and Francesco Fanfani and Giovanni Scambia and Andrea Fattorossi},
  journal={Immunology},
  year={2008},
  volume={123 1},
  pages={129-38}
}
We examined the phenotype and function of CD4+ T cells expressing the semaphorin III receptor neuropilin-1 (Nrp1) in human lymph nodes and peripheral blood. In lymph nodes, Nrp1 identified a small regulatory CD4+ CD25(high) T-cell subpopulation (Nrp1+ Treg) that expressed higher levels of Forkhead box P3 (Foxp3) message and protein than Nrp1- Treg, and various molecular markers of activated Treg, i.e. CD45RO, human leucocyte antigen (HLA)-DR and glucocorticoid-induced tumour necrosis factor… CONTINUE READING

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