Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.

@article{Staton2013Neuropilin1AN,
  title={Neuropilin-1 and neuropilin-2 expression in the adenoma-carcinoma sequence of colorectal cancer.},
  author={Carolyn Ann Staton and Ivan Koay and Jessie M. Wu and Leslie Hoh and Malcolm W. R. Reed and Nicola J Brown},
  journal={Histopathology},
  year={2013},
  volume={62 6},
  pages={908-15}
}
AIMS Neuropilin-1 (NRP1) and neuropilin-2 (NRP2) are transmembrane glycoproteins which interact with vascular endothelial growth factor (VEGF) to prevent tumour cell apoptosis and regulate angiogenesis. However, the precise role of NRP1 and NRP2 in the adenoma-carcinoma sequence (ACS) of colorectal cancer remains unclear, and we aimed to determine this in surgical specimens comprising the ACS. METHODS AND RESULTS Histological analysis demonstrated that epithelial NRP1 expression increased… CONTINUE READING
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