Neurophysiology of pruritus: cutaneous elicitation of itch.

  title={Neurophysiology of pruritus: cutaneous elicitation of itch.},
  author={Sonja St{\"a}nder and Martin Steinhoff and Martin Schmelz and Elke Weisshaar and Dieter Metze and Thomas Anton Luger},
  journal={Archives of dermatology},
  volume={139 11},
Itching is defined as an unpleasant cutaneous sensation leading to the desire to scratch. It serves as a physiological self-protective mechanism as do other cutaneous sensations like pain, touch, vibration, cold, and heat to help defend the skin against harmful external agents. Pruritus can be evoked in the skin directly by mechanical and thermal stimuli or indirectly through chemical mediators. It may also be generated in the central nervous system independently of peripheral stimulation… CONTINUE READING
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