Neurophysiology of HCN channels: From cellular functions to multiple regulations

  title={Neurophysiology of HCN channels: From cellular functions to multiple regulations},
  author={Chao He and Fang Chen and Bo Li and Zhi-an Hu},
  journal={Progress in Neurobiology},
Hyperpolarization-activated cyclic nucleotide-gated (HCN) cation channels are encoded by HCN1-4 gene family and have four subtypes. These channels are activated upon hyperpolarization of membrane potential and conduct an inward, excitatory current Ih in the nervous system. Ih acts as pacemaker current to initiate rhythmic firing, dampen dendritic excitability and regulate presynaptic neurotransmitter release. This review summarizes recent insights into the cellular functions of Ih and… CONTINUE READING
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