Neurophysiology: Hodgkin and Huxley model — still standing?

  title={Neurophysiology: Hodgkin and Huxley model — still standing?},
  author={David A. McCormick and Yousheng Shu and Yuguo Yu},
Arising from: B. Naundorf, F. Wolf & M. Volgushev 440, 1060–1063 (2006); Naundorf et al. replyAction potentials in cortical neurons show a variable threshold and a sudden rise in membrane potential at initiation. Naundorf et al. fail to explain these features using single- or double-compartment Hodgkin–Huxley-style models, suggesting instead that they could arise from cooperative opening of Na+ channels, although there is no direct biological evidence to support this. Here we show that these so… CONTINUE READING

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