Neurophysiology: Hodgkin and Huxley model — still standing?

@article{McCormick2007NeurophysiologyHA,
  title={Neurophysiology: Hodgkin and Huxley model — still standing?},
  author={D. McCormick and Y. Shu and Y. Yu},
  journal={Nature},
  year={2007},
  volume={445},
  pages={E1-E2}
}
  • D. McCormick, Y. Shu, Y. Yu
  • Published 2007
  • Physics, Medicine
  • Nature
  • Arising from: B. Naundorf, F. Wolf & M. Volgushev 440, 1060–1063 (2006); Naundorf et al. replyAction potentials in cortical neurons show a variable threshold and a sudden rise in membrane potential at initiation. Naundorf et al. fail to explain these features using single- or double-compartment Hodgkin–Huxley-style models, suggesting instead that they could arise from cooperative opening of Na+ channels, although there is no direct biological evidence to support this. Here we show that these so… CONTINUE READING

    Figures and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    Paper Mentions

    Active properties of neocortical pyramidal neuron dendrites.
    • 251
    • PDF
    What Is the Most Realistic Single-Compartment Model of Spike Initiation?
    • 45
    • PDF
    Action Potential Initiation in the Hodgkin-Huxley Model
    • 28
    • PDF
    Fitting Neuron Models to Spike Trains
    • 71
    • Highly Influenced
    • PDF
    Hodgkin–Huxley Models
    • 8
    A Threshold Equation for Action Potential Initiation
    • 159
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 26 REFERENCES
    The generation of impulses in motoneurones
    • 266