Neurophysiological properties of pallidal neurons in Parkinson's disease.

  title={Neurophysiological properties of pallidal neurons in Parkinson's disease.},
  author={Djordje Sterio and Aleksandar Beri{\'c} and Michael Dogali and Eugene Fazzini and Gilberto Alfaro and Orrin Devinsky},
  journal={Annals of neurology},
  volume={35 5},
Neuronal properties of the human globus pallidus (GP) are not known. Since GP is the major output of the basal ganglia, it may be involved in the pathophysiology of Parkinson's disease. We studied 12 patients with medically resistant Parkinson's disease by using single cell recording of the GP during stereotaxic pallidotomy to define neuronal firing rate and its modulation during active and passive movements. Different frequency and pattern of single cell activity was found in globus pallidus… CONTINUE READING


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