Neurophysiological correlates of age-related changes in working memory updating

  title={Neurophysiological correlates of age-related changes in working memory updating},
  author={Jamie E. Podell and Fabio Sambataro and Vishnu P. Murty and Matthew R. Emery and Yunxia Tong and Saumitra Das and Terry E. Goldberg and Daniel R. Weinberger and Venkata S. Mattay},
Normal aging is associated with a gradual decline in executive functions such as set-shifting, inhibition, and updating, along with a progressive decline of neurotransmitter systems including the dopamine system. Modulation from the dopamine system is thought to be critical for the gating of information during working memory. Given the known relationships between executive aging, cognition, and dopamine, this study aims to explore the neurobiology underlying age-related changes in working… CONTINUE READING


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