Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia.

@article{Xu1999NeurophysiologicalCA,
  title={Neurophysiological changes associated with selective neuronal damage in hippocampus following transient forebrain ischemia.},
  author={Zao Cheng Xu and Tian M Gao and Yubo Ren},
  journal={Biological signals and receptors},
  year={1999},
  volume={8 4-5},
  pages={294-308}
}
Neurophysiological changes of hippocampal neurons were compared before and after transient forebrain ischemia using intracellular recording and staining techniques in vivo. Ischemic depolarization (ID) was used as an indication of severe ischemia. Under halothane anesthesia, approximately 13 min of ID consistently produced severe neuronal damage in the CA1 region of rat hippocampus, while CA3 pyramidal neurons and dentate granule cells remained intact. After such severe ischemia, approximately… CONTINUE READING
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