Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies.

@article{Carozzi2010NeurophysiologicalAN,
  title={Neurophysiological and neuropathological characterization of new murine models of chemotherapy-induced chronic peripheral neuropathies.},
  author={Valentina Alda Carozzi and Annalisa Canta and Norberto Oggioni and Barbara Sala and Alessia Chiorazzi and Cristina Meregalli and Mario Bossi and Paola Marmiroli and Guido Cavaletti},
  journal={Experimental neurology},
  year={2010},
  volume={226 2},
  pages={301-9}
}
Cisplatin, paclitaxel and bortezomib belong to some of the most effective families of chemotherapy drugs for solid and haematological cancers. Epothilones represent a new family of very promising antitubulin agents. The clinical use of all these drugs is limited by their severe peripheral neurotoxicity. Several in vivo rat models have reproduced the characteristics of the peripheral neurotoxicity of these drugs. However, since only a very limited number of cancer types can be studied in… CONTINUE READING