Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine

@inproceedings{Santarnecchi2015NeurophysiologicalCO,
  title={Neurophysiological Correlates of Central Fatigue in Healthy Subjects and Multiple Sclerosis Patients before and after Treatment with Amantadine},
  author={Emiliano Santarnecchi and Simone Rossi and Sabina Bartalini and Massimo Cincotta and Fabio Giovannelli and Elisa Tatti and Monica Ulivelli},
  booktitle={Neural plasticity},
  year={2015}
}
In ten healthy subjects and in ten patients suffering from Multiple Sclerosis (MS), we investigated the cortical functional changes induced by a standard fatiguing repetitive tapping task. The Cortical Silent Period (CSP), an intracortical, mainly GABAB-mediated inhibitory phenomenon, was recorded by two different hand muscles, one acting as prime mover of the fatiguing index-thumb tapping task (First Dorsal Interosseous, FDI) and the other one not involved in the task but sharing largely… CONTINUE READING
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