Neurophysiologic changes during estrogen augmentation in perimenopausal depression.

  title={Neurophysiologic changes during estrogen augmentation in perimenopausal depression.},
  author={Melinda L. Morgan and Ian A. Cook and Andrea J. Rapkin and Andrew F. Leuchter},
  volume={56 1},
BACKGROUND Estrogen augmentation of antidepressant medication has been an effective treatment in a subgroup of women experiencing affective symptoms during perimenopause. It has been suggested that estrogen facilitates serotonergic transmission in brain regions involved in mood disorders. We investigated differences in physiologic brain changes with estrogen augmentation in women with perimenopausal depression who reached remission compared to those who did not reach remission. We also assessed… CONTINUE READING