Neuropharmacology of venlafaxine.

  title={Neuropharmacology of venlafaxine.},
  author={Patrick H. Roseboom and Ned H. Kalin},
  journal={Depression and anxiety},
  volume={12 Suppl 1},
Venlafaxine (Effexor) is an effective antidepressant and has also been approved for the treatment of generalized anxiety disorder. Venlafaxine was initially characterized as an inhibitor of both serotonin (5HT) and norepinephrine (NE) uptake and was therefore termed a "dual uptake inhibitor." This chapter reviews data from both in vitro and in vivo studies regarding its effects on 5HT and NE neurotransmission. In addition, the effects of venlafaxine on other systems that may play a role in its… CONTINUE READING
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