Neuropharmacology of 5-hydroxytryptamine.

  title={Neuropharmacology of 5-hydroxytryptamine.},
  author={Alfred Richard Green},
  journal={British journal of pharmacology},
  volume={147 Suppl 1},
This review outlines the history of our knowledge of the neuropharmacology of 5-hydroxytryptamine (5-HT; serotonin), focusing primarily on the work of U.K. scientists. The existence of a vasoconstrictive substance in the blood has been known for over 135 years. The substance was named serotonin and finally identified as 5-HT in 1949. The presence of 5-HT in the brain was reported by Gaddum in 1954 and it was Gaddum who also demonstrated that the action of 5-HT (in the gut) was antagonised by… CONTINUE READING


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