Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria

@article{Carolis2004NeuropharmacologicalIO,
  title={Neuropharmacological investigations on muscimol, a psychotropic drug extracted from Amanita muscaria},
  author={Arsenia Scotti de Carolis and Filippo Lipparini and Vincenzo G. Longo},
  journal={Psychopharmacologia},
  year={2004},
  volume={15},
  pages={186-195}
}
SummaryThe effects of muscimol on the EEG and on the spontaneous and conditioned behavior of cats, rabbits, and rats were studied. High voltage 3 c/sec. waves appear in the EEG tracing of rabbits and rats treated with 0.5–1 mg/kg of the drug; after higher doses (2 mg/kg) spikes appear, intermingled with the slow waves. Administration of eserine (0.2 mg/kg) only slightly influences the EEG “synchronization” induced by muscimol. Muscimol-treated rabbits receiving small doses of diazepam or… 
Physiological and behavioral studies with muscimol
TLDR
Behavioral studies with muscimol remain difficult to interpret in terms of central GABAergic systems, especially since muscIMol is extensively metabolized and since it appears to interact with membrane sites other than GABA receptors.
Fungal Hallucinogens Psilocin, Ibotenic Acid, and Muscimol: Analytical Methods and Biologic Activities
TLDR
The present article offers an opportunity to find out what are the main symptoms of intoxication with mushrooms containing psilocybin/psilocin, muscimol, and ibotenic acid.
Amanita muscaria : chemistry , biology , toxicology , and ethnomycology 131
TLDR
Current knowledge on the chemistry, toxicology, and biology relating to this mushroom is reviewed, together with distinctive features concerning this unique species.
Amanita muscaria: chemistry, biology, toxicology, and ethnomycology.
TLDR
Current knowledge on the chemistry, toxicology, and biology relating to this mushroom is reviewed, together with distinctive features concerning this unique species.
Toxicological and pharmacological profile of Amanita muscaria (L.) Lam. – a new rising opportunity for biomedicine
TLDR
The rising pharmacological and toxicological interest based on lots of contradictive opinions concerning the use of Amanita muscaria extracts’ neuroprotective role against some neurodegenerative diseases such as Parkinson’s and Alzheimer’'s gave the basis for this review.
Homotaurine and muscimol mimic taurine and gaba effects on muscle tone and temperature regulation
SummaryTaurine, homotaurine, GABA and muscimol, given intraventricularly to the conscious, unrestrained rabbit cause hypothermia and a reduction in skeletal muscle tone. Taurine and homotaurine
FLORIDA INTERNATIONAL UNIVERSITY Miami, Florida JAPANESE USE OF BENI-TENGU-DAKE (AMANITA MUSCARIA) AND THE EFFICACY OF TRADITIONAL DETOXIFICATION
OF THE THESIS JAPANESE USE OF BENI-TENGU-DAKE (AMANITA MUSCARIA) AND THE EFFICACY OF TRADITIONAL DETOXIFICATION METHODS by Allan Grady Phipps Florida International University, 2000 Miami, Florida
Muscimol and the uptake of γ-aminobutyric acid by rat brain slices
Muscimol is a weak, non-competitive inhibitor (Ki1.2×10−3 M) of the uptake of γ-aminobutyric acid by slices of rat cerebral cortex.
...
...

References

SHOWING 1-10 OF 12 REFERENCES
Electroencephalographic and behavioral analysis of drug effects on an instrumental reward discrimination in rabbits
TLDR
The present study presents a comparison of the behavioral and E E G effects of several compounds on the performance of the simple instrumental response and of the discrimination of rabbits.
EEG and behavioral effects of 2-5-methoxy-4-methyl-amphetamine (DOM, STP).
The pharmacology of Amanita muscaria.
  • P. Waser
  • Psychology, Medicine
    Psychopharmacology bulletin
  • 1967
Isolation, structure and synthesis of central -active compounds from Amanita musearia
  • publication of the U.S. Dept. of Health, Education and Welfare
  • 1967
Effects de certains hallueinog~nes sur I'EEG et le comportement conditionn6 du lapin
  • Th6rapie 20,
  • 1965
Lo~Go: EEG and behavioural effects of 2--5 methoxy-4-methyl-amphetamine (DOM, STP)
  • Arch. int. Pharmaeodyn. (In press)
  • 1969
...
...