Neuropharmacological basis for multimodal analgesia in chronic pain

  title={Neuropharmacological basis for multimodal analgesia in chronic pain},
  author={Ryan Patel and Anthony Henry Dickenson},
  journal={Postgraduate Medicine},
  pages={245 - 259}
ABSTRACT Managing chronic pain remains a major unmet clinical challenge. Patients can be treated with a range of interventions, but pharmacotherapy is the most common. These include opioids, antidepressants, calcium channel modulators, sodium channel blockers, and nonsteroidal anti-inflammatory drugs. Many of these drugs target a particular mechanism; however, chronic pain in many diseases is multifactorial and induces plasticity throughout the sensory neuroaxis. Furthermore, comorbidities such… 

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