Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.

@article{Crawley1985NeuropharmacologicalAO,
  title={Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.},
  author={Jacqueline N. Crawley and Philip T Ninan and David Pickar and George P. Chrousos and Markku Linnoila and Phil Skolnick and Steven M Paul},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1985},
  volume={5 2},
  pages={477-85}
}
A behavioral and physiological syndrome of stress-related responses was reported in primates following treatment with the benzodiazepine receptor antagonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE). The behavioral and physiological effects of beta-CCE are similar to those observed during stressful or "anxiety"-related conditions characterized in rhesus monkeys under natural conditions. Pharmacological agents which are known to antagonize anxiety responses in other paradigms were… CONTINUE READING

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