Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.

  title={Neuropharmacological antagonism of the beta-carboline-induced "anxiety" response in rhesus monkeys.},
  author={Jacqueline N. Crawley and Philip T Ninan and David Pickar and George P. Chrousos and Markku Linnoila and Phil Skolnick and Steven M Paul},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={5 2},
A behavioral and physiological syndrome of stress-related responses was reported in primates following treatment with the benzodiazepine receptor antagonist, beta-carboline-3-carboxylic acid ethyl ester (beta-CCE). The behavioral and physiological effects of beta-CCE are similar to those observed during stressful or "anxiety"-related conditions characterized in rhesus monkeys under natural conditions. Pharmacological agents which are known to antagonize anxiety responses in other paradigms were… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 18 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

Alterations in the function of the nucleus locus coeruleus: A possible model for studies of anxiety

  • D. E. Redmond
  • In Animal Models
  • 1977
Highly Influential
3 Excerpts

Effects of THIP on chronic anxiety

  • Hunkeler. N.. H. Mohler. L. Pieri. P. Pole. E. P. Bonetti. R Schaffner, W. Haefeley
  • Psycho - pharmacology
  • 1983

The benzodiazepine antagonist Ro 15-1788 antagonizes the behavioral efzects of cyproheptadine

  • J. E. Barrett, L. S. Brady
  • Pharmacologist
  • 1983
2 Excerpts

An in vitro binding assay which differentiates benzodiazepine “agonists” and “antagonists.

  • M. Paul
  • Eur . , J . Pharmacol .
  • 1982

Similar Papers

Loading similar papers…