Neuropeptides shaping the central nervous system development: Spatiotemporal actions of VIP and PACAP through complementary signaling pathways

  title={Neuropeptides shaping the central nervous system development: Spatiotemporal actions of VIP and PACAP through complementary signaling pathways},
  author={Tando L. Maduna and Vincent Leli{\`e}vre},
  journal={Journal of Neuroscience Research},
Pituitary adenylate cyclase–activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP) are neuropeptides with wide, complementary, and overlapping distributions in the central and peripheral nervous systems, where they exert important regulatory roles in many physiological processes. VIP and PACAP display a large range of biological cellular targets and functions in the adult nervous system including regulation of neurotransmission and neuroendocrine secretion and neuroprotective… 

Relationship between constitutive and acute gene regulation, and physiological and behavioral responses, mediated by the neuropeptide PACAP

It is shown that there is a cohort of genes (constitutively PACAP regulated genes, or cPRGs) whose basal expression is affected by constitutive knock-out of the Adcyap1 gene in C57Bl6/N mice, and additional genes whose expression in response to physiological challenge, in adults, is altered or impaired in the absence of PACAP expression.

Targeting the neurological comorbidities of multiple sclerosis: the beneficial effects of VIP and PACAP neuropeptides.

The final scope of the review is to put more emphasis on how targeting the VIP/PACAP system may be an effective therapeutic strategy to modify MS disease course and its associated comorbidities.

Early Neurobehavioral Development of Mice Lacking Endogenous PACAP

The results show that mice lacking endogenous PACAP have slower weight gain during the first weeks of development and slower neurobehavioral development regarding a few developmental hallmarks.

Current Evidence for a Role of Neuropeptides in the Regulation of Autophagy

Recent advances on the role exerted by neuropeptides in the control of autophagy and its molecular mechanisms are described since increasing evidence indicates that dysregulation of Autophagic process is related to different pathological conditions, including neurodegeneration, metabolic disorders, and cancer.

Altered Notch Signaling in Developing Molar Teeth of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP)-Deficient Mice

The lack of PACAP leads to upregulation of Notch pathway elements in the odontoblast and ameloblast cells, which could represent a salvage pathway in PACAP-deficient animals.

Pituitary adenylate cyclase-activating polypeptide (PACAP) in zebrafish models of nephrotic syndrome

It is reported, for the first time, PACAP deficiency in a NS zebrafish model as a consequence of adriamycin exposure and the renoprotective effects of the PACAP-38 peptide against adRIamycin toxicity in zebra fish are extended.

Potentials of Neuropeptides as Therapeutic Agents for Neurological Diseases

The natural roles of neuropeptides in the modulation of neurological function and the development of neurological disorders are examined and the potential of these proteinaceous molecules in filling gaps in current therapeutics are highlighted.

La fotosíntesis cumple horas extras

The results during the past decade demonstrated that galectin-1 (Gal-1) controls immune and/or vascular homeostasis through multiple regulatory mechanisms, and recent studies highlighting the role of Gal-1 as a novel target in cancer, inflammation and autoimmunity are discussed.

Peptidomic Analysis of Fetal Heart Tissue for Identification of Endogenous Peptides Involved in Tetralogy of Fallot.

This study constructed a comparative peptidomic profile from the heart tissues of TOF fetuses and normal controls, and it identified a series of peptides that could potentially participate in heart development and TOF formation.



VPAC and PAC receptors: From ligands to function.

VIP and PACAP: recent insights into their functions/roles in physiology and disease from molecular and genetic studies

PACAP/VIP as well as their three classes of receptors are important in many physiological/pathophysiological processes, some of which are identified in these studies using knockout animals, which may lead to new novel treatment approaches.

Pharmacology and functions of receptors for vasoactive intestinal peptide and pituitary adenylate cyclase‐activating polypeptide: IUPHAR Review 1

The existing nomenclature for these receptors is confirmed, the current understanding of their structure, pharmacology and functions and their likely physiological roles in health and disease are reviewed.

VPAC receptors: structure, molecular pharmacology and interaction with accessory proteins

Recent advances in the structural characterization of VPAC receptor and more generally of class B GPCRs will lead to the design of new molecules, which could have considerable interest for the treatment of inflammatory and neuro‐degenerative diseases.

Noncompensation in peptide/receptor gene expression and distinct behavioral phenotypes in VIP‐ and PACAP‐deficient mice

The results suggest that the PACAP and VIP have evolved to possess distinct biological activities and intimate that the respective knockout phenotypes represent deficits unmitigated by the actions of the complementary related peptide.

Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery

The present report reviews the current knowledge concerning the pleiotropic actions of PACAP and discusses its possible use for future therapeutic applications.

VIP and PACAP Receptor‐Mediated Actions on Cell Proliferation and Survival

  • J. Waschek
  • Biology
    Annals of the New York Academy of Sciences
  • 1996
Although neuropeptides have been traditionally known as neurotransmitters and neuromodulators, an emerging concept is that neuropePTides have important actions during development.

Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide.

Results suggest that 1) a saturable, high affinity binding site for PACAP is present on anterior pituitary membranes; 2) PACAP27 and PACAP38, but not VIP, share this binding site in the anterior pituitsary and possibly the hypothalamus; and 3)PACAP27, PACAP 38, and VIP share a similar or identical binding site on lung membranes and possibly other peripheral tissues.

VIP and PACAP induce selective neuronal differentiation of mouse embryonic stem cells

It is demonstrated that functional GPCRs for VIP and PACAP are present on ES cells and that these neuropeptides may induce their differentiation into a neuronal phenotype, opening an exciting new field for neuropepeptide regulation of tissue ontogenesis.