Neuropeptides in the cerebral circulation.

  title={Neuropeptides in the cerebral circulation.},
  author={Rolf Uddman and Lars Edvinsson},
  journal={Cerebrovascular and brain metabolism reviews},
  volume={1 3},
The occurrence and distribution of peptide-containing nerve fibers to the cerebral circulation are described. Immunocytochemical studies have revealed that cerebral blood vessels are invested with nerve fibers containing neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), peptide histidine isoleucine (PHI), substance P (SP), neurokinin A (NKA), and calcitonin gene-related peptide (CGRP). In addition, there are studies reporting the occurrence of putative neurotransmitters such as… CONTINUE READING