Neuropeptides in Migraine and Cluster Headache

  title={Neuropeptides in Migraine and Cluster Headache},
  author={Lars Edvinsson and P. J. Goadsby},
  pages={320 - 327}
The cerebral circulation is invested by a rich network of neuropeptide Y (NPY) and noradrenaline containing sympathetic nerve fibers in arteries, arterioles and veins. However, the nerve supply of vasoactive intestinal peptide (VIP), substance P (SP) and calcitonin gene-related peptide (CGRP) containing fibers is sparse. While noradrenaline and NPY cause vasoconstriction, VIP, SP and CGRP are potent vasodilators. Stimulation of the trigeminal ganglion in cat and man elicits release of SP and… 

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