Neuropeptides as positive or negative neuronal growth regulatory factors: effects of ACTH and leu-enkephalin on cultured serotonergic neurons.

@article{DavilaGarcia1990NeuropeptidesAP,
  title={Neuropeptides as positive or negative neuronal growth regulatory factors: effects of ACTH and leu-enkephalin on cultured serotonergic neurons.},
  author={M I Davila-Garcia and Efrain Charles Azmitia},
  journal={Advances in experimental medicine and biology},
  year={1990},
  volume={265},
  pages={75-92}
}
In summary, we have presented evidence that neuropeptides can function as either positive or negative growth regulatory factors during development. The ACTH family of peptides appear to act predominantly as a positive growth regulatory factor-enhancing neurite outgrowth, cell survival, biochemical maturation and behavioral expression. These effects of ACTH are most pronounced prior to the time the afferent cell has reached its target. Thus, ACTH may act as a low level general neurotrophic… CONTINUE READING