Neuropeptides: From Gene Regulation to Protein Processing


Angiotensin-converting enzyme (ACE) and the Alzheimer’s disease amyloid precursor protein are two examples of membrane-bound proteins that are released in a soluble form by a post-translational proteolytic cleavage event involving a secretase. Site-specific antibodies and matrixassisted laser desorption ionization-time-of-flight (‘MALDI-TOF ’) MS have been… (More)


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