Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?

@article{Griebel2012NeuropeptideRL,
  title={Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?},
  author={G. E. Griebel and Florian Holsboer},
  journal={Nature Reviews Drug Discovery},
  year={2012},
  volume={11},
  pages={462-478}
}
The search for novel drugs for treating psychiatric disorders is driven by the growing medical need to improve on the effectiveness and side-effect profile of currently available therapies. Given the wealth of preclinical data supporting the role of neuropeptides in modulating behaviour, pharmaceutical companies have been attempting to target neuropeptide receptors for over two decades. However, clinical studies with synthetic neuropeptide ligands have been unable to confirm the promise… CONTINUE READING
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