Neuropeptide processing and its impact on melanocortin pathways.

  title={Neuropeptide processing and its impact on melanocortin pathways.},
  author={Lynn E Pritchard and Anne R White},
  volume={148 9},
Proopiomelanocortin (POMC) is processed in an intracellular secretory pathway, primarily to enable release of ACTH from the pituitary and alpha-MSH from hypothalamic neurons and skin. However, processing is incomplete and unprocessed POMC is secreted from all three tissues. This review considers intracellular processing of neuronal POMC as a key checkpoint that controls flux through hypothalamic melanocortin receptor pathways. Regulation of the convertase, proprotein convertase (PC)-1/3, which… CONTINUE READING
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