Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.

  title={Neuropeptide neurotensin stimulates intestinal wound healing following chronic intestinal inflammation.},
  author={Paola Brun and Cristina Mastrotto and Elisa Beggiao and Annalisa Stefani and Luisa Barzon and Giacomo carlo Sturniolo and Giorgio Pal{\`u} and Ignazio Castagliuolo},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  volume={288 4},
Because neurotensin (NT) and its high-affinity receptor (NTR1) modulate immune responses, chloride secretion, and epithelial cell proliferation, we sought to investigate their role in the repair process that follows the development of mucosal injuries during a persistent inflammation. Colonic NT and NTR1, mRNA, and protein significantly increased only after dextran sodium sulfate (DSS)-induced inflammatory damage developed. Colitis-induced body weight loss, colonic myeloperoxidase activity, and… CONTINUE READING


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