Neuropeptide modulators of high mobility group box 1 secretion as potential therapeutic agents for severe sepsis.

Sepsis is a potentially life-threatening condition caused by infection and characterized by a poorly controlled systemic inflammatory response. Severe sepsis is sepsis with the evidence of acute organ system dysfunction, and septic shock is sepsis associated with systemic arterial hypotension. Severe sepsis remains a huge public health problem. In the… (More)