Neuropeptide expression in rats exposed to chronic mild stresses

  title={Neuropeptide expression in rats exposed to chronic mild stresses},
  author={Valeriy Sergeyev and Serguei O Fetissov and Aleksander A. Math{\'e} and Patricia Jim{\'e}nez and Tamas Bartfai and Patrick Mortas and Laurent Gaudet and J. V. Moreau and Tomas G M H{\"o}kfelt},
To investigate a possible link between some neuropeptides and depression, we analyzed their mRNA levels in brains of rats exposed to chronic mild stresses (CMS; a stress-induced anhedonia model), a commonly used model of depression. Rats exposed for 3 weeks to repeated, unpredictable, mild stressors exhibited an increased self-stimulation threshold, reflecting the development of an anhedonic state, which is regarded as an animal model of major depression. In situ hybridization was employed to… CONTINUE READING


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